Posted by
Pioneers on Saturday, June 20, 2009 12:00:00 AM
?Drug name?
English name: Cefminox Sodium for Injection
Hanyu Pinyin: Zhusheyong Toubaominuona
The main ingredients of this product Cefminox sodium,
its chemical name: (6R, 7S)-7β-[(S) -2 - [(2 - amino--2 - carboxy
ethyl) thiourea] acetyl]-7α - methoxy -3 - [[(1 - methyl-1H-tetrazol -5
- yl) sulfur] methyl] -8 - oxo -5 - thia -1 - azabicyclo [4.2.0 ] oct -2 - ene -2 - carboxylic acid sodium salt hydrate 7.
Molecular formula: C16H20N7NaO7S3.7H2O
Molecular Weight: 667.66
?Characters?
This product is a white to light yellow crystalline powder.
?Pharmaco-toxicological?
This product of Gram-positive bacteria and gram-negative bacteria have a broad-spectrum antibacterial activity, especially for E. coli,
Klebsiella spp, Haemophilus influenzae, Proteus mirabilis, and
vulnerability are Bacteroides has a strong antibacterial effect. Its
mechanism of β-lactam antibiotic penicillin is usually the role of
point-binding protein showed a strong affinity, inhibit cell wall
synthesis, and peptide-binding inhibiting peptidoglycan binding and to
promote the bacteriolytic lipoprotein in a short period of time showed
a strong bactericidal. This product is a view of the proliferation of bacteria and have shown stability in the early period of antimicrobial activity, which is lower than the concentration of MIC also has bactericidal action, a short period of time bacteriolysis. In vivo antibacterial MIC forecasts than more.
This
product is injected 200 ~ 1600mg/kg / day no female reproductive
capacity of rats, rats differentiation and reproductive capacity
development impact. Injection
of rabbits 400 ~ 1600mg/kg / day, a total of 5 in the 800mg/kg / day
treatment group and above, the observed nephrotoxicity of cefazolin
than weak, but slightly Cefalotin. In mice, rats, guinea pigs and rabbits almost no antigenicity. And cefmetazole, cefazolin, penicillin G, ampicillin no immunological cross-between, but also no positive Coombs's reaction.
?Pharmacokinetics?
This
product is for adults with normal renal function showed a
dose-dependent manner, the average plasma elimination half-life to 2.5
hours. This
product in the sputum of patients with chronic bronchitis in patients
with peritonitis and ascites in patients with bile, endometrial,
ovarian, fallopian tube can be achieved in the treatment of
concentration.
Cefminox sodium in the human body there is no anti-bacterial active metabolite. Mainly from renal excretion, 12-hour urinary excretion rate of about 90%. Varying
degrees of renal dysfunction in patients with the extension of its
elimination half-life, moderate and severe renal damage (Ccr <l0)
24-hour urinary excretion rate of about 10%, moderate damage (Ccr ˜ 48)
12-hour urinary excretion rate is about 60%.
?Indications?
Sensitive for the treatment of the above-mentioned product can cause bacterial infection of the following:
1. Respiratory
infections: tonsillitis, peritonsillar abscess, bronchitis,
bronchiolitis, bronchiectasis (infection), secondary infection of
chronic respiratory disease, pneumonia, suppurative pulmonary disease.
2.Urinary tract infections: Pyelonephritis, cystitis.
3.Intra-abdominal infections: cholecystitis, cholangitis, peritonitis.
4.Pelvic
infection: pelvic peritonitis, uterine annex inflammation,
intra-uterine infections, pelvic dead space inflammation, inflammation
of uterine tissue.
5.Sepsis.
?Usage consumption? This product is used only for intravenous injection or intravenous infusion administration.
Intravenous
injection: intravenous injection in each 1g (potency) 20ml water for
injection of drugs available, 5% ~ 10% glucose injection fluid 0.9%
sodium chloride injection dissolved.
Intravenous
drip: intravenous drip in each 1g (potency) of drug can be used 100 ~
500ml5% ~ 10% glucose injection fluid 0.9% sodium chloride injection
dissolved infusion 1 to 2 hours.
Commonly
recommended dose is: Adults each 1g (potency), 1, 2, may be appropriate
to increase or decrease with age and symptoms, for sepsis, refractory
disease or severe infection, 1, may be increased to 6g (titer), 3 ~ 4
hours dose; each child according to the weight of 20mg (potency) / kg,
1 3 ~ 4 times.
This product should be temporary preparation, dissolved as soon as possible after use.
?Adverse Reactions? This product adverse reactions observed after the listing of adverse reactions are as follows:
Incidence: rare: less than 0.1%, sometimes: 0.1 ~ 5%, common: 5% or more, or the unknown frequency.
1)
dual shock? serious side effects caused by shock, should be to observe
if there discomfort, foreign body sensation in the mouth, wheezing,
dizziness, then Italy, tinnitus, sweating, etc., should be stopped and
appropriate disposal.
?
pancytopenia occur even pancytopenia, there should be regular checks
are carried out to observe, if unusual, should be stopped and
appropriate disposal.
? pseudome colitis occur even go far pseudome of the large intestine accompanied by severe bloody colitis, it is to observe, when abdominal pain, frequent diarrhea, drug withdrawal should be quick and proper disposal.
2)
similar drugs serious side effects observed in the eyes ? mucocutaneous
syndrome (Stevens-Johnson syndrome), toxic epidermal necrosis (Lyell
syndrome) other cephalosporin antibiotic vinyl dolls eyes appear
mucocutaneous syndrome (Stevens - Johnson syndrome), toxic epidermal
necrosis (Lyell syndrome) report, there to observe, if unusual, should
be stopped and appropriate disposal.
?Acute
renal failure other cephalosporin antibiotic vinyl even there, such as
acute renal failure in the report of severe kidney damage, it is
unusual to be stopped and appropriate disposal.
?Hemolytic
anemia vinyl other cephalosporin antibiotics, there is the report of
hemolytic anemia should be inspected regularly and so on, to observe,
if unusual, should be stopped and appropriate disposal.
?interstitial
pneumonia, PIE syndrome, other cephalosporin antibiotics occasionally
occur with vinyl fever, cough, difficulty in breathing, chest X-ray
abnormalities, such as eosinophilia of interstitial pneumonia, PIE
syndrome, such as the report of If such symptoms appear,
discontinuation should be and to adrenocorticotropic hormone
preparations such as, proper disposal.
3)Other
side effects sometimes ? allergy rash, even skin redness, itching,
fever, etc., if such symptoms occur, and proper disposal should stop.
?dual kidney appeared increased BUN, blood creatinine increased, oliguria, proteinuria and other renal injury, we can see
that there should be regular checks are carried out to observe if there
oliguria, hematuria, and urinary protein, etc., BUN increased, blood
creatinine increased such as inspection, we can see that should be stopped and appropriate disposal.
?sometimes
blood neutropenia, eosinophilia, red blood cells even appeared to
reduce, lower hematocrit values, hemoglobin decrease in
thrombocytopenia, such as prothrombin time should be regular checks are
carried out to observe, if the abnormal should be stopped and
appropriate disposal.
?sometimes liver GOT, GPT, AL-P rise, arise even γ-GTP, LAP, LDH, increased bilirubin and jaundice, etc., should be to observe, if unusual, should be stopped and appropriate disposal.
?diarrhea
and sometimes the digestive tract, even nausea, vomiting, loss of
appetite and so on, it is to observe, if unusual, should be stopped and
appropriate disposal.
?flora occur even turn stomatitis disease, candidiasis.
?
vitamin deficiency of vitamin K occur even the absence of symptoms (low
prothrombin levels, bleeding tendency, etc.), vitamin B group of the
lack of symptoms (glossitis, stomatitis, loss of appetite, neuritis,
etc.).
?other dual sense of generalized weakness occur.
?Taboo?
Cefminox disabled or on vinyl cephalosporin antibiotic allergic patients.
?Notes?
Product can be caused by shock, diagnosis should be carefully before use, if the use of skin test should be carried out. Shock first-aid ready to do a good job, to observe the post-administration.
? on the β-lactam antibiotic used with caution in patients with a history of allergy.
? I-or two-parent, brother have bronchial asthma, skin rash, urticaria, such as those used with caution allergy.
? serious caution in patients with renal dysfunction.
? elderly patients should be medication use in elderly patients.
? renal dysfunction adjustable doses.
?
lack of oral feeding in patients with non-oral nutrition in patients
with maintenance of body status in patients with non-performing [the
possibility of lack of symptoms of vitamin K] be used with caution.
?
alcohol may cause facial flushing, palpitations, dizziness, headache,
nausea, etc., so drug use during and after treatment to avoid alcohol
for at least 1 week.
?Pregnant women and lactating women use?
Animal
reproductive test Cefminox sodium does not appear to have any
reproductive or embryos, but in pregnant women have not carried out any
tests, medication safety during pregnancy has not been established, so
only when necessary in order to use this drug for pregnant women. Breast-feeding women the drug should be used with caution.
?Child medication ?
Newborns,
premature infants have not yet established the safety of drugs; full
moon after the use of pediatric medication dosage? ?reference.
?Medication in elderly patients ?
It
should be noted: more common physiological function in elderly patients
with lower incidence of adverse effects easily, there may be a lack of
vitamin K caused by the bleeding tendency, it is prudent administration.
?Drug interactions?
This
product with aminophylline, pyridoxal phosphate combined effect would
reduce the price or coloring, it may not be compatible; and furans
Thiamine, lipoic acid, hydrocortisone sodium succinate and adenosine
mecobalamin longer be later combined discoloration, it should be
combined as soon as possible after use; and diuretics (p-furans acid,
etc.) are likely to increase sharing of renal toxicity, should be used
with caution. Animal
studies confirmed that the impact of the products of alcohol
metabolism, so that an increase in blood acetaldehyde concentrations, indicating the role of Disulfiram-like, they use during or after drug prohibition.
?Specification? (1) 0.5g (2) 1.0g (to C16H21N7O7S3 dollars)
?Storage? shading, sealed and preserved in a cool dry place.
?Packing? resistant packaging bottles, 10 bottles / box.
Reference: Google
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Source From:
Pioneers Group