Description:

Albendazole Bolus is a unique broad spectrum anthelmintic for control of multiple helminth infestation, viz nematodes, cestodes and trematodes.

Indications:

A broad spectrum anthelmintic for treatment of gastrointestinal infestation of ringworms, lungworms, tapeworms, liver flukes and amphistomes. Albendazole has also an ovicidal effect.

Dosage:

For roundworms / tapeworms

Cattle / buffalo / horse / sheep / goat: 5mg/kg bodyweight

Dog / cat: 10 to 25mg/kg bodyweight

For flukes

Cattle/buffalo: 10mg/kg bodyweight

Sheep/goat: 7.5mg/kg bodyweight

Multiple dosing at 2-3 weeks interval enhances flukicidal activity of albendazole against flukes in cattle and sheep. Periodic deworming (once in 3-4 months) in all species of domestic and zoo animals with albendazole is advocated for successful anthelmintic effect.

Reprinted from: Pioneer Group's Albendazole

Q: What's Tylosin?

A: Tylosin is a macrolide-class antibiotic used in veterinary medicine. It has a broad spectrum of activity against gram positive organisms and a limited range of gram negative organisms.It is found naturally as a fermentation product of Streptomyces fradiae.
    Tylosin is used in veterinary medicine to treat bacterial infections in a wide range of species and has a high margin of safety.It has also been used as a growth promotant in some species, and as a treatment for colitis in companion animals.


And there's a photo of Tylosin injection:


Reprinted from: Pioneers Group

When we use Albendazole, we should know the Dosage of Albendazole.
From Google and Wiki, we can learn that:

Hydatid disease:

• Patients 60 kg or greater: 400 mg twice daily, with meals.
• Patients less than 60 kg: 15 mg/kg/day given in divided doses twice daily with meals (maximum total daily dose 800 mg).
• Treatment interval: 28-day cycle followed by a 14-day albendazole-free interval, for a total of 3 cycles.

NOTE: When administering albendazole in the pre- or post-surgical setting, optimal killing of cyst contents is achieved when 3 courses of therapy have been given.

Neurocysticerosis:

• Patients 60 kg or greater: 400 mg twice daily, with meals.
• Patients less than 60 kg: 15 mg/kg/day given in divided doses twice daily with meals (maximum total daily dose 800 mg).
• Treatment interval: 8-30 days.

Note: Patients being treated for neurocysticercosis should receive appropriate steroid and anticonvulsant therapy as required. Oral or intravenous corticosteroids should be considered to prevent cerebral hypertensive episodes during the first week of treatment.

Reference: Googel, Wiki
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Reprinted from: China Pioneers

Q: What is albendazole?

A: Albendazole is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.

Albendazole is used to treat certain infections caused by worms such as pork tapeworm and dog tapeworm.

Albendazole may also be used for other purposes not listed in this medication guide.

We Provide Albendazole Bolus,Albendazole & Ivermectin Tablets and Albendazole & Ivermectin Tablets.

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Reprinted from: China Pioneers

Reference: Google, Drugs.Com

Don't use Analgesic Agents before or after Drinking.

Doctors say, after the liquor enters the human body, generally stay in the stomach about half an hour, only about 20% -30% will be absorbed by the remaining small bowel, duodenum, absorption, and then transported to the liver metabolism of the blood. Medication during the alcohol may be the secretion of enzyme inhibitors to slow down the metabolism of certain drugs, resulting in drug accumulation, increased efficacy. In addition, during the medication every day to drink, drugs may also promote enzyme secretion, so that drugs enhance the activity of enzymes can lead to speed up the metabolism of certain drugs to reduce the effect. Therefore, after using the drugs,we must be careful to drink.

Before or after drinking,Don't use the following drugs: cephalosporins (Pioneer Pioneer ? ADM ADM ?, Hartridge bacteria); sedative and hypnotic drugs (such as phenobarbital, chloral hydrate, stable and Chlordiazepoxide) ; antipyretic analgesic agents (aspirin, paracetamol) and reserpine, anticancer, drugs such Isonicotinic swollen.

Diclofenac Sodium Tablets Photo:


Reference: Google

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Source From: Pioneers Group

?Drug name?
English name: Cefminox Sodium for Injection
Hanyu Pinyin: Zhusheyong Toubaominuona
The main ingredients of this product Cefminox sodium, its chemical name: (6R, 7S)-7β-[(S) -2 - [(2 - amino--2 - carboxy ethyl) thiourea] acetyl]-7α - methoxy -3 - [[(1 - methyl-1H-tetrazol -5 - yl) sulfur] methyl] -8 - oxo -5 - thia -1 - azabicyclo [4.2.0 ] oct -2 - ene -2 - carboxylic acid sodium salt hydrate 7.

Molecular formula: C16H20N7NaO7S3.7H2O
Molecular Weight: 667.66
?Characters?
This product is a white to light yellow crystalline powder.
?Pharmaco-toxicological?
This product of Gram-positive bacteria and gram-negative bacteria have a broad-spectrum antibacterial activity, especially for E. coli, Klebsiella spp, Haemophilus influenzae, Proteus mirabilis, and vulnerability are Bacteroides has a strong antibacterial effect. Its mechanism of β-lactam antibiotic penicillin is usually the role of point-binding protein showed a strong affinity, inhibit cell wall synthesis, and peptide-binding inhibiting peptidoglycan binding and to promote the bacteriolytic lipoprotein in a short period of time showed a strong bactericidal. This product is a view of the proliferation of bacteria and have shown stability in the early period of antimicrobial activity, which is lower than the concentration of MIC also has bactericidal action, a short period of time bacteriolysis.  In vivo antibacterial MIC forecasts than more.
This product is injected 200 ~ 1600mg/kg / day no female reproductive capacity of rats, rats differentiation and reproductive capacity development impact.  Injection of rabbits 400 ~ 1600mg/kg / day, a total of 5 in the 800mg/kg / day treatment group and above, the observed nephrotoxicity of cefazolin than weak, but slightly Cefalotin. In mice, rats, guinea pigs and rabbits almost no antigenicity.  And cefmetazole, cefazolin, penicillin G, ampicillin no immunological cross-between, but also no positive Coombs's reaction.
?Pharmacokinetics?
This product is for adults with normal renal function showed a dose-dependent manner, the average plasma elimination half-life to 2.5 hours.  This product in the sputum of patients with chronic bronchitis in patients with peritonitis and ascites in patients with bile, endometrial, ovarian, fallopian tube can be achieved in the treatment of concentration.
Cefminox sodium in the human body there is no anti-bacterial active metabolite.  Mainly from renal excretion, 12-hour urinary excretion rate of about 90%.  Varying degrees of renal dysfunction in patients with the extension of its elimination half-life, moderate and severe renal damage (Ccr <l0) 24-hour urinary excretion rate of about 10%, moderate damage (Ccr ˜ 48) 12-hour urinary excretion rate is about 60%.
?Indications?
Sensitive for the treatment of the above-mentioned product can cause bacterial infection of the following:
1. Respiratory infections: tonsillitis, peritonsillar abscess, bronchitis, bronchiolitis, bronchiectasis (infection), secondary infection of chronic respiratory disease, pneumonia, suppurative pulmonary disease.
2.Urinary tract infections: Pyelonephritis, cystitis.
3.Intra-abdominal infections: cholecystitis, cholangitis, peritonitis.
4.Pelvic infection: pelvic peritonitis, uterine annex inflammation, intra-uterine infections, pelvic dead space inflammation, inflammation of uterine tissue.
5.Sepsis.
?Usage consumption? This product is used only for intravenous injection or intravenous infusion administration.
Intravenous injection: intravenous injection in each 1g (potency) 20ml water for injection of drugs available, 5% ~ 10% glucose injection fluid 0.9% sodium chloride injection dissolved.
Intravenous drip: intravenous drip in each 1g (potency) of drug can be used 100 ~ 500ml5% ~ 10% glucose injection fluid 0.9% sodium chloride injection dissolved infusion 1 to 2 hours.
Commonly recommended dose is: Adults each 1g (potency), 1, 2, may be appropriate to increase or decrease with age and symptoms, for sepsis, refractory disease or severe infection, 1, may be increased to 6g (titer), 3 ~ 4 hours dose; each child according to the weight of 20mg (potency) / kg, 1 3 ~ 4 times.
This product should be temporary preparation, dissolved as soon as possible after use.
?Adverse Reactions? This product adverse reactions observed after the listing of adverse reactions are as follows:
Incidence: rare: less than 0.1%, sometimes: 0.1 ~ 5%, common: 5% or more, or the unknown frequency.
1) dual shock? serious side effects caused by shock, should be to observe if there discomfort, foreign body sensation in the mouth, wheezing, dizziness, then Italy, tinnitus, sweating, etc., should be stopped and appropriate disposal.
? pancytopenia occur even pancytopenia, there should be regular checks are carried out to observe, if unusual, should be stopped and appropriate disposal.
? pseudome colitis occur even go far pseudome of the large intestine accompanied by severe bloody colitis, it is to observe, when abdominal pain, frequent diarrhea, drug withdrawal should be quick and proper disposal.
2) similar drugs serious side effects observed in the eyes ? mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrosis (Lyell syndrome) other cephalosporin antibiotic vinyl dolls eyes appear mucocutaneous syndrome (Stevens - Johnson syndrome), toxic epidermal necrosis (Lyell syndrome) report, there to observe, if unusual, should be stopped and appropriate disposal.
?Acute renal failure other cephalosporin antibiotic vinyl even there, such as acute renal failure in the report of severe kidney damage, it is unusual to be stopped and appropriate disposal.
?Hemolytic anemia vinyl other cephalosporin antibiotics, there is the report of hemolytic anemia should be inspected regularly and so on, to observe, if unusual, should be stopped and appropriate disposal.
?interstitial pneumonia, PIE syndrome, other cephalosporin antibiotics occasionally occur with vinyl fever, cough, difficulty in breathing, chest X-ray abnormalities, such as eosinophilia of interstitial pneumonia, PIE syndrome, such as the report of If such symptoms appear, discontinuation should be and to adrenocorticotropic hormone preparations such as, proper disposal.
3)Other side effects sometimes ? allergy rash, even skin redness, itching, fever, etc., if such symptoms occur, and proper disposal should stop.
?dual kidney appeared increased BUN, blood creatinine increased, oliguria, proteinuria and other renal injury, we can see that there should be regular checks are carried out to observe if there oliguria, hematuria, and urinary protein, etc., BUN increased, blood creatinine increased such as inspection, we can see that should be stopped and appropriate disposal.
?sometimes blood neutropenia, eosinophilia, red blood cells even appeared to reduce, lower hematocrit values, hemoglobin decrease in thrombocytopenia, such as prothrombin time should be regular checks are carried out to observe, if the abnormal should be stopped and appropriate disposal.
?sometimes liver GOT, GPT, AL-P rise, arise even γ-GTP, LAP, LDH, increased bilirubin and jaundice, etc., should be to observe, if unusual, should be stopped and appropriate disposal.
?diarrhea and sometimes the digestive tract, even nausea, vomiting, loss of appetite and so on, it is to observe, if unusual, should be stopped and appropriate disposal.
?flora occur even turn stomatitis disease, candidiasis.
? vitamin deficiency of vitamin K occur even the absence of symptoms (low prothrombin levels, bleeding tendency, etc.), vitamin B group of the lack of symptoms (glossitis, stomatitis, loss of appetite, neuritis, etc.).
?other dual sense of generalized weakness occur.
?Taboo?
Cefminox disabled or on vinyl cephalosporin antibiotic allergic patients.
?Notes?
Product can be caused by shock, diagnosis should be carefully before use, if the use of skin test should be carried out. Shock first-aid ready to do a good job, to observe the post-administration.
? on the β-lactam antibiotic used with caution in patients with a history of allergy.
? I-or two-parent, brother have bronchial asthma, skin rash, urticaria, such as those used with caution allergy.
? serious caution in patients with renal dysfunction.
? elderly patients should be medication use in elderly patients.
? renal dysfunction adjustable doses.
? lack of oral feeding in patients with non-oral nutrition in patients with maintenance of body status in patients with non-performing [the possibility of lack of symptoms of vitamin K] be used with caution.
? alcohol may cause facial flushing, palpitations, dizziness, headache, nausea, etc., so drug use during and after treatment to avoid alcohol for at least 1 week.
?Pregnant women and lactating women use?
Animal reproductive test Cefminox sodium does not appear to have any reproductive or embryos, but in pregnant women have not carried out any tests, medication safety during pregnancy has not been established, so only when necessary in order to use this drug for pregnant women. Breast-feeding women the drug should be used with caution.
?Child medication ?
 Newborns, premature infants have not yet established the safety of drugs; full moon after the use of pediatric medication dosage? ?reference.
?Medication in elderly patients ?
It should be noted: more common physiological function in elderly patients with lower incidence of adverse effects easily, there may be a lack of vitamin K caused by the bleeding tendency, it is prudent administration.
?Drug interactions?
This product with aminophylline, pyridoxal phosphate combined effect would reduce the price or coloring, it may not be compatible; and furans Thiamine, lipoic acid, hydrocortisone sodium succinate and adenosine mecobalamin longer be later combined discoloration, it should be combined as soon as possible after use; and diuretics (p-furans acid, etc.) are likely to increase sharing of renal toxicity, should be used with caution. Animal studies confirmed that the impact of the products of alcohol metabolism, so that an increase in blood acetaldehyde concentrations, indicating the role of Disulfiram-like, they use during or after drug prohibition.
?Specification? (1) 0.5g (2) 1.0g (to C16H21N7O7S3 dollars)
?Storage? shading, sealed and preserved in a cool dry place.
?Packing? resistant packaging bottles, 10 bottles / box.

Reference: Google

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Source From: Pioneers Group

Concept:

   Anti-infective agents with means to kill or inhibit the role of a variety of pathogenic microorganisms, can be oral, intramuscular injection, intravenous injection of a variety of applications, such as systemic antibiotics, sulfonamides and quinolones, as well as other chemical pharmaceuticals drugs (isoniazid, a Sodium triazole, nitrofurantoin, PPA, etc.).


The rational use of anti-infective agents:

1. Should be familiar with the selection of drug resistant microorganisms in the original activity, pharmacokinetics, indications and adverse reactions.

2. To establish an early etiological diagnosis. The right to establish a reasonable choice of the pathogen was a prerequisite for anti-infective agents. Some conventional methods of pathogen should also not be easily separated as much as possible to use alternative diagnostic technologies, including a variety of immunological tests. Isolation and identification of pathogenic bacteria should be as much as possible for the drug sensitivity (susceptibility) the determination and, if necessary, and to conduct joint drug sensitivity test for the selection of drug reference, which deal with serious systemic infection is particularly important.

3. Should be in patients with physiological and pathological immune status, such as rational drug use. Neonatal hypoplasia enzymes in vivo, drug plasma protein binding capacity of the weaker, lower glomerular filtration rate, most of the elderly reduce plasma protein, also decreased renal function, after the application of conventional-dose serum concentration and half-life are often increased and extended, so a small amount of appropriate conditions should be regularly monitored at the plasma peak concentration Valley.

4. Topical application of anti-infective agents to prevent or to avoid strict control should be a clear indication for a small number of persons; as for the prevention of coma, shock, such as patients with infections, or cleaning to prevent infection after surgery is often futile .

   Should try to avoid skin and mucous membrane, such as local application of anti-infective agents, as easily cause an allergic reaction, but also easy to have led to drug-resistant. Therefore, in addition to the main drug for local application, such as neomycin, bacitracin, mupirocin, sulfonamides Miloon endures for the treatment of other major systemic infection, especially in the local application of penicillin to try to avoid.

5. Combined with the need for a clear anti-infective indications. Most of the clinical anti-infective agents can be infected with a control, only to increase the joint use and treatment costs of adverse reactions.

6. Should be used for program delivery, dose and treatment. Intravenous administration should not be used for mild to moderate infections. Should be based on pharmacokinetic parameters of the development of drug delivery program. Excessive doses are not affordable or too small, too small to have no therapeutic effect, anti-bacteria may be resistant to; agent too prominent example is the penicillins, is not only a waste of serious and easy to line-induced central nervous system toxicity and electrolyte balance disorders and other adverse reactions.

   Applications should normally be sustained anti-infective agents to the body temperature normal, the symptoms subsided within 72 ~ 96 hours, but sepsis, infective endocarditis, osteomyelitis, purulent meningitis, typhoid fever, brucellosis, tuberculosis and other cases not. Such as the effects of medication could not acute infection in 48 ~ 72 hours should consider changing or adjusting drug dosage.

Reference: Google

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Source From: Pioneers Group

PIONEERS GROUP is dedicated to pharmaceutical industry. PIONEERS can provide total pharmaceutical solution, from API (active pharmaceutical ingredient) to generic finished products, either human drugs or veterinary products, from single machine to turn-key project. PIONEERS is extending our business in every aspect of this industry.

PIONEERS owns an excellent team, which consists of technical experts and business elites working in this field for many years. In Pioneers, we say "staff first", because all our core competition is coming from these staff who are full of energy and dare to challenge the market.

PIONEERS as the name shows, acts as a avant-courier in pharmaceutical industry. we have built strategic partnerships with main pharmaceutical companies, and we are one of the first to distribute veterinary products to Middle East and Africa. we are one of the main exporters who introduce Chinese pharmaceutical machines abroad

PIONEERS’ slogan is " We Bring The Change " means:

China is recognized as " Workshop of World " PIONEERS is ready to discover more benefit for the customers. Because we have good talents and enough experience in this market. PIONEERS commit ourselves to the product quality, we execute strict quality control procedures and only purchase from approved and qualified sources. In additional, working in this field for many years, we have much experience about import/export conventions, drug regulations, even culture difference in many countries. Therefore, we are able to meet versatile requests and offer you best service. Every customer is making innovation to meet the change of world. PIONEERS would like to take this challenge. we utilizes good expertise to fix the exchange rate and reduce the loss due to RMB up value, PIONEERS has good logistics system duly delivering from 100 gram parcel courier to thousands tons bulk ship; our experts can be consultor for GMP Plant turn key project, and give the preliminary design free of charge.

This is PIONEERS. Here you will find a good partner you desire.

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This Blog is Our Company's Unofficial Blog.

From Wiki, we can learn that, Veterinary medicine is the application of medical, diagnostic, and therapeutic principles to companion, domestic, exotic, wildlife, and production animals. Veterinary science is vital to the study and protection of animal production practices, herd health and monitoring the spread of disease. It requires the acquisition and application of scientific knowledge in multiple disciplines and uses technical skills directed at disease prevention in both domestic and wild animals.