?Drug name?
English name: Cefminox Sodium for Injection
Hanyu Pinyin: Zhusheyong Toubaominuona
The main ingredients of this product Cefminox sodium, its chemical name: (6R, 7S)-7β-[(S) -2 - [(2 - amino--2 - carboxy ethyl) thiourea] acetyl]-7α - methoxy -3 - [[(1 - methyl-1H-tetrazol -5 - yl) sulfur] methyl] -8 - oxo -5 - thia -1 - azabicyclo [4.2.0 ] oct -2 - ene -2 - carboxylic acid sodium salt hydrate 7.
Molecular formula: C16H20N7NaO7S3.7H2O
Molecular Weight: 667.66
?Characters?
This product is a white to light yellow crystalline powder.
?Pharmaco-toxicological?
This product of Gram-positive bacteria and gram-negative bacteria have a broad-spectrum antibacterial activity, especially for E. coli, Klebsiella spp, Haemophilus influenzae, Proteus mirabilis, and vulnerability are Bacteroides has a strong antibacterial effect. Its mechanism of β-lactam antibiotic penicillin is usually the role of point-binding protein showed a strong affinity, inhibit cell wall synthesis, and peptide-binding inhibiting peptidoglycan binding and to promote the bacteriolytic lipoprotein in a short period of time showed a strong bactericidal. This product is a view of the proliferation of bacteria and have shown stability in the early period of antimicrobial activity, which is lower than the concentration of MIC also has bactericidal action, a short period of time bacteriolysis.  In vivo antibacterial MIC forecasts than more.
This product is injected 200 ~ 1600mg/kg / day no female reproductive capacity of rats, rats differentiation and reproductive capacity development impact.  Injection of rabbits 400 ~ 1600mg/kg / day, a total of 5 in the 800mg/kg / day treatment group and above, the observed nephrotoxicity of cefazolin than weak, but slightly Cefalotin. In mice, rats, guinea pigs and rabbits almost no antigenicity.  And cefmetazole, cefazolin, Penicillin G Procaine , ampicillin no immunological cross-between, but also no positive Coombs's reaction.
?Pharmacokinetics?
This generic pharmaceuticals product is for adults with normal renal function showed a dose-dependent manner, the average plasma elimination half-life to 2.5 hours.  This product in the sputum of patients with chronic bronchitis in patients with peritonitis and ascites in patients with bile, endometrial, ovarian, fallopian tube can be achieved in the treatment of concentration.
Cefminox sodium in the human body there is no anti-bacterial active metabolite.  Mainly from renal excretion, 12-hour urinary excretion rate of about 90%.  Varying degrees of renal dysfunction in patients with the extension of its elimination half-life, moderate and severe renal damage (Ccr
?Indications?
Sensitive for the treatment of the above-mentioned product can cause bacterial infection of the following:
1. Respiratory infections: tonsillitis, peritonsillar abscess, bronchitis, bronchiolitis, bronchiectasis (infection), secondary infection of chronic respiratory disease, pneumonia, suppurative pulmonary disease.
2.Urinary tract infections: Pyelonephritis, cystitis.
3.Intra-abdominal infections: cholecystitis, cholangitis, peritonitis.
4.Pelvic infection: pelvic peritonitis, uterine annex inflammation, intra-uterine infections, pelvic dead space inflammation, inflammation of uterine tissue.
5.Sepsis.
?Usage consumption? This generic pharmaceuticals product is used only for intravenous injection or intravenous infusion administration.
Intravenous injection: intravenous injection in each 1g (potency) 20ml water for injection of drugs available, 5% ~ 10% glucose injection fluid 0.9% sodium chloride injection dissolved.
Intravenous drip: intravenous drip in each 1g (potency) of drug can be used 100 ~ 500ml5% ~ 10% glucose injection fluid 0.9% sodium chloride injection dissolved infusion 1 to 2 hours.
Commonly recommended dose is: Adults each 1g (potency), 1, 2, may be appropriate to increase or decrease with age and symptoms, for sepsis, refractory disease or severe infection, 1, may be increased to 6g (titer), 3 ~ 4 hours dose; each child according to the weight of 20mg (potency) / kg, 1 3 ~ 4 times.
This product should be temporary preparation, dissolved as soon as possible after use.

from:china-pharmaceutical-generic

Albendazole , marketed as Albenza, Eskazole, Zentel and Andazol, is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. Although this use is widespread in the United States, the U.S. Food and Drug Administration (FDA) has not approved albendazole for this indication. It is marketed by GlaxoSmithKline.

 As a vermicidal, albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

Albendazole also has been shown to inhibit the enzyme fumarate reductase, which is helminth-specific. This action may be considered secondary to the effect on the microtubules due to the decreased absorption of glucose. This action occurs in the presence of reduced amounts of nicotinamide-adenine dinucleotide in reduced form (NADH), which is a coenzyme involved in many cellular oxidation-reduction reactions.

Albendazole has larvicidal effects in necatoriasis and ovicidal effects in ascariasis, ancylostomiasis, and trichuriasis.

from:wiki

• Albendazole is an "antihelmintic," or anti-worm, medication. It prevents worms from growing or multiplying in your body.
• Albendazole is used to treat infections caused by worms such as pork tapeworm and dog tapeworm.
• Albendazole may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about albendazole?

• Do not take albendazole if you are pregnant. Avoid pregnancy for at least 1 month following albendazole therapy.
• Do not take albendazole without first talking to your doctor if you are breast-feeding a baby.
• You may require a lower dose or special monitoring during therapy if you have liver problems.
• Take albendazole with food to lessen stomach upset.

How should I take albendazole?

• Take albendazole exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
• Take each dose with a full glass of water.
• Take albendazole tablets with food to lessen stomach upset.
• Take all of the albendazole that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated. It can take 30 days to 3 months to treat this infection.
• Fasting, laxatives, or purging will not help to cure this infection.
• Store albendazole at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

• Seek emergency medical attention or call a poison control left near you.

What should I avoid while taking albendazole?

• Do not take albendazole if you are pregnant. Avoid pregnancy for at least 1 month following treatment with albendazole.
• There are no restrictions on foods, beverages, or activities while you are taking albendazole unless your doctor directs otherwise.

What are the possible side effects of albendazole?

• Stop taking albendazole and seek emergency medical attention if you experience an allergic reaction (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or hives).
• Other, less serious side effects may be more likely to occur. Continue to take albendazole and talk to your doctor if you experience
  • abdominal pain, nausea, or vomiting;
  • headache;
  • dizziness ;or
  • a fever.

What drug(s) may interact with albendazole?

• aminophyline
• caffeine
• carbamazepine
• cimetidine
• clozapine
• dexamethasone
• grapefruit juice
• mexiletine
• olanzapine
• phenobarbital
• phenytoin
• ropinirole
• tacrine
• theophyline
• warfarin

 From: http://www.china-pharmaceutical-generic.com/news/index.html

Albendazole is used for treating certain tapeworm infections.

In addition to intestinal helminths, many Haitians are infected by a tiny worm in the blood which can lead to elephantiasis, immense swelling of the legs. We are approaching several drug manufacturers of DEC, a medicine which kills the worms causing that disease.

The International Action staff works closely with the Center for Disease Control and the Pan American Health Organization in these medical programs. We are forming a Medical Advisory Board of public health and nursing officials to oversee this work.

How to use:

Use Albendazole as directed by your doctor.

    * Take Albendazole by mouth with food.
    * If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water.

Ask your health care provider any questions you may have about how to use Albendazole. Drug Class and Mechanism

Albendazole is an anthelmintic. It works by killing sensitive parasites.

Missed Dose:

If you miss a dose of Albendazole and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Storage

Store Albendazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Albendazole out of the reach of children and away from pets.

Description:

Albendazole Bolus is a unique broad spectrum anthelmintic for control of multiple helminth infestation, viz nematodes, cestodes and trematodes.

Indications:

A broad spectrum anthelmintic for treatment of gastrointestinal infestation of ringworms, lungworms, tapeworms, liver flukes and amphistomes. Albendazole has also an ovicidal effect.

Dosage:

For roundworms / tapeworms

Cattle / buffalo / horse / sheep / goat: 5mg/kg bodyweight

Dog / cat: 10 to 25mg/kg bodyweight

For flukes

Cattle/buffalo: 10mg/kg bodyweight

Sheep/goat: 7.5mg/kg bodyweight

Multiple dosing at 2-3 weeks interval enhances flukicidal activity of albendazole against flukes in cattle and sheep. Periodic deworming (once in 3-4 months) in all species of domestic and zoo animals with albendazole is advocated for successful anthelmintic effect.

Reprinted from: Pioneer Group's Albendazole

Hydatid disease:

• Patients 60 kg or greater: 400 mg twice daily, with meals.
• Patients less than 60 kg: 15 mg/kg/day given in divided doses twice daily with meals (maximum total daily dose 800 mg).
• Treatment interval: 28-day cycle followed by a 14-day albendazole-free interval, for a total of 3 cycles.

NOTE: When administering albendazole in the pre- or post-surgical setting, optimal killing of cyst contents is achieved when 3 courses of therapy have been given.

Neurocysticerosis:

• Patients 60 kg or greater: 400 mg twice daily, with meals.
• Patients less than 60 kg: 15 mg/kg/day given in divided doses twice daily with meals (maximum total daily dose 800 mg).
• Treatment interval: 8-30 days.

Note: Patients being treated for neurocysticercosis should receive appropriate steroid and anticonvulsant therapy as required. Oral or intravenous corticosteroids should be considered to prevent cerebral hypertensive episodes during the first week of treatment.

Q: What is albendazole?

A: Albendazole is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.

Albendazole is used to treat certain infections caused by worms such as pork tapeworm and dog tapeworm.

Albendazole may also be used for other purposes not listed in this medication guide.

We Provide Albendazole Bolus,Albendazole & Ivermectin Tablets and Albendazole & Ivermectin Tablets.

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Reprinted from: China Pioneers